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Michel Boisbrun Selected Research

Troglitazone (Rezulin)

2/2020New desulfured troglitazone derivatives: Improved synthesis and biological evaluation.
10/2017Pro-apoptotic effect of Δ2-TGZ in "claudin-1-low" triple-negative breast cancer cells: involvement of claudin-1.
1/2016Reprofiling of Troglitazone Towards More Active and Less Toxic Derivatives: A New Hope for Cancer Treatment?
5/2012Synthesis of new troglitazone derivatives: anti-proliferative activity in breast cancer cell lines and preliminary toxicological study.
5/2011EGR1 expression: a calcium and ERK1/2 mediated PPARγ-independent event involved in the antiproliferative effect of 15-deoxy-Δ12,14-prostaglandin J2 and thiazolidinediones in breast cancer cells.
11/2010New troglitazone derivatives devoid of PPARγ agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines.
12/2008Disruption of ERalpha signalling pathway by PPARgamma agonists: evidences of PPARgamma-independent events in two hormone-dependent breast cancer cell lines.

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Michel Boisbrun Research Topics

Disease

9Breast Neoplasms (Breast Cancer)
06/2022 - 12/2008
8Neoplasms (Cancer)
02/2020 - 07/2003
5Triple Negative Breast Neoplasms
06/2022 - 05/2012
1Cerebrovascular Disorders (Cerebrovascular Occlusion)
06/2021
1Cardiovascular Diseases (Cardiovascular Disease)
06/2021
1Metabolic Syndrome (Dysmetabolic Syndrome X)
10/2018
1Starvation
12/2016
1Prostatic Neoplasms (Prostate Cancer)
11/2014
1Drug Hypersensitivity (Drug Allergy)
02/2012
1Parasitemia
07/2010
1Necrosis
07/2003

Drug/Important Bio-Agent (IBA)

7Hormones (Hormone)IBA
06/2022 - 12/2008
7Troglitazone (Rezulin)FDA Link
02/2020 - 12/2008
3PPAR gammaIBA
05/2015 - 12/2008
3ThiazolidinedionesIBA
05/2015 - 05/2011
3ciglitazoneIBA
11/2014 - 12/2008
2Claudin-1IBA
10/2017 - 10/2017
2Rosiglitazone (Avandia)FDA Link
05/2011 - 12/2008
22,4-thiazolidinedione (thiazolidinedione)IBA
11/2010 - 12/2008
1TubulinIBA
06/2022
1Type 1 Angiotensin ReceptorIBA
06/2021
1Angiotensin Receptor AntagonistsIBA
06/2021
1ArrestinIBA
06/2021
1Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
06/2021
1Angiotensin IIIBA
10/2018
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
10/2018
1Bovine Serum AlbuminIBA
12/2016
1Cytostatic AgentsIBA
12/2016
1Caspase 7IBA
05/2015
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
05/2015
1Deoxyglucose (2 Deoxy D glucose)IBA
11/2014
1Immunoglobulin E (IgE)IBA
02/2012
1LigandsIBA
05/2011
1CalciumIBA
05/2011
1Messenger RNA (mRNA)IBA
05/2011
1Pharmaceutical PreparationsIBA
11/2010
1VitaminsIBA
11/2010
1Estrogen Receptor alphaIBA
12/2008
1PresenilinsIBA
07/2003
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
07/2003
1Metalloproteases (Metalloproteinases)IBA
07/2003
1DisintegrinsIBA
07/2003
1EnzymesIBA
07/2003

Therapy/Procedure

5Therapeutics
06/2021 - 12/2008
2Investigational Therapies (Experimental Therapy)
06/2022 - 10/2017
1Oral Administration
07/2010